Microscopic image of a cyanoacrylate biopsy. The cell structure is clearly visible.

Intercellular and follicular penetration of topically applied substances

Intercellular and follicular penetration of topically applied substances, penetration kinetics, lateral spreading, storage and action of topically applied drugs.

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Methods

  • Tape stripping in combination with spectroscopic measurements for quantitative determination of applied substances and corneocytes
  • Differential stripping (combination of tape stripping and cyanoacrylate skin surface biopsy) for separate analysis of intercellular and follicular penetration
  • Laser scanning microscopy of histological sections for the determination of the follicular penetration depth of topically applied substances
  • Selective closing of hair follicles in vivo and in vitro on Franz diffusion cells
  • In vivo laser scanning microscopy
  • In vivo Raman spectroscopy
  • In vivo Raman microspectroscopy
  • Electron paramagnetic resonance based studies on penetration enhancement and storage of drugs
  • Microdialysis