Photographic image of a Laser scanning microscopy in vivo measurement on the arm of a person.

Inside-out penetration

Mechanism of appearance of systemically applied substances on human skin; recovery of antioxidants on the skin surface; systemic sun protection; inverse drug delivery; pathomechanism of palmo-plantar erythrodysaesthesia; prevention of cutaneous side effects after systemic application of drugs (e. g., chemotherapy).

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Methods

Depiction of a sweat gland with doxorubicin recorded by Laser scanning microscopy.
Sweat gland with doxorubicin recorded by Laser scanning microscopy. Photo: H. Richter/Charité.

  • In vivo laser scanning microscopy
  • Raman micro-spectroscopy
  • Resonance Raman spectroscopy
  • Two-photon microscopy
  • Mass spectroscopy
  • High-pressure liquid chromatography
  • Ion mobility spectrometry
  • X-ray spectroscopy