Center of Experimental and Applied Cutaneous Physiology 

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Depiction of the collagen and elastin structure in human skin by in vivo Laser scanning microscopy. Collagen is shown in white.

Development and evaluation of anti-aging strategies

Analysis of the efficiency of topically applied anti-aging creams and sunscreens, determination of their protection properties (absorption, reflection, etc.) and the efficacy of neutralization of free radicals produced by solar radiation and by other stress factors in the skin, analysis of changes in the collagen and elastin structure during topical or systemic treatment or influence of stress factors, analysis of the systemic, topical and combined treatment of the skin with antioxidants contained in nutrition supplements, evaluation of the intensity of the influence of stress factors on the skin.

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Methods

The diagramm exemplarily shows the furrow depth in the skin. Furrows of 150 µm depths can be seen.
Skin surface structure of aged skin. Photo: H. Richter/Charité.
  • In vivo resonance Raman spectroscopy
  • In vivo Raman microscopy
  • Two photon microscopy
  • electron paramagnetic resonance spectroscopy
  • UV-VIS- NIR spectroscopy
  • Analysis of the skin surface structure (skin roughness)
  • Confocal Raman microscopy
Photographic image of a multi-photon tomograph for in vivo measurements with the measurement site for subjects.
In vivo multi-photon microscope. Photo: H. Richter/Charité.