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False-color image of a hair follicle. The penetrated nanoparticles in the follicle and on the skin surface are shown in red.

Research topics of the Center of Experimental and Applied Cutaneous Physiology (CCP)

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Research Topics of the CCP

There are three main areas of research at the CCP, all of which are carried out with the aid of innovative methods. These include predominantly non-invasive spectroscopic and imaging methods, which can be applied to skin cells, skin models and predominantly also in vivo on humans. They are used to study the interaction of the skin with influencing factors such as. Sunlight, environmental pollution, but also nutrition and therapeutic applications for skin diseases. Furthermore, they are used for the characterization of healthy skin but also for the diagnosis of skin diseases and therapy monitoring. Here, machine learning supports the data analysis. The skin has a strong barrier against external influences. The study and overcoming of this barrier for the introduction of active substances represents the third focus. Aids such as nanocarriers can protect and selectively release the active ingredients, improve penetration and serve as reservoirs.

Imaging and spectroscopic techniques at the CCP are used for studies of Interaction of stress and skin, Drug delivery and Diagnostics.
Research structure CCP. Foto: M. Meinke/Charité.

The research structure of the CCP

  • Remote UVC application, skin antisepsis, safety evaluation
  • Development of methods for pollution measurement and evaluation of antipollution products
  • Interaction of antioxidants and free radicals in the skin
  • Characterization of sunscreens
  • Sunscreen and other non-invasive in vivo measurements to determine the sun protection factor
  • Application of cold physical plasma for wound healing
  • Determination and optimization of penetration of topically applied substances
  • Support of nanoparticles in topical formulations: Prospects and risk assessment
  • Development and evaluation of anti-aging strategies
  • Skin physiology of healthy and diseased skin
  • Non-invasive single cell detection in vivo
  • Automatic analysis of spectra and image data (machine learning)

Available methods/devices

  • OCT (OCT)
  • Multiphotontomography (MPT) with Fluorescence Lifetime Imaging (FLIM)
  • Laser Scanning Microscopy (LSM)
  • Confocal Raman Microscopy (CRM)
  • Resonant Raman Spectroscopy (RRS)
  • Electron Spin Resonance Spectroscopy (ESR)
  • Microdialysis
  • Differential tape stripping
  • Automatic data analysis (Machine Learning)
  • Surface profilometry
  • Ex-vivo and in-vivo exposure chamber for cigarette smoke