The skin is a stable barrier that impedes the uptake of topically applied substances. Hair follicles (HF) are an interesting target site for delivery of topically applied substances due to the weaker follicular barrier. However, non-particulate substances, including solubilized agents, virtually do not penetrate the HF, have very limited bioavailability, or do not pass through the skin barrier at all.
The team has developed a method for improved particle-mediated transport of solutes into the HF. This project will determine the best conditions for optimal HF penetration of the drug ex vivo and demonstrate a proof-of-concept of drug delivery and initial validation in vivo.
If successful, this new mode of enhanced drug delivery will be broadly applicable, and we plan to explore its use for additional agents and indications.
Duration: 02/2023 - 12/2024
Funded by: Berlin Institute of Health
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